Short-term Results of Hematopoietic Stem Cell Transplantation for Children with Myelodysplastic Syndrome.
- Author:
Jin LEE
1
;
Soh Yeon KIM
;
Bin CHO
;
Pil Sang JANG
;
Nak Gyun CHUNG
;
Hack Ki KIM
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. chobinkr@cmc.kuk.ac.kr
- Publication Type:Original Article
- Keywords:
Myelodysplastic syndrome(MDS);
Hematopoietic stem cell transplantation(HSCT)
- MeSH:
Adult;
Anemia, Refractory, with Excess of Blasts;
Child;
Fetal Blood;
Follow-Up Studies;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Humans;
Leukemia, Myeloid, Acute;
Myelodysplastic Syndromes*;
Prognosis;
Recurrence;
Siblings;
Stem Cells;
Survival Rate
- From:Journal of the Korean Pediatric Society
2002;45(3):370-375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed. METHODS: Ten children with MDS(CMMoL 5, RAEB 3, RAEBt 2) underwent HSCT(HLA- matched sibling transplantation 4, HLA-matched unrelated transplantation 4, cord blood transplantation 1, HLA-mismatched familial transplantation 1) between November 1995 and January 2001 at St. Mary's Hospital. Median follow-up duration was 11 months. RESULTS: Engraftment was successful in all cases and 8 patients are alive without disease. Three cases of VOD were observed and improved without complication. Four cases of grade II and 1 case of grade III acute GVHD were observed and well controlled with treatment. Three patients relapsed after transplantation. One patient is alive without disease after cytoreduction with allogenic stem cell rescue and 2 patients died of relapse. CONCLUSION: HSCT is a curative strategy of MDS and the survival rate is relatively higher than that of adults. But there is an obvious need for more studies because of the small number of patients and the short duration of the follow-up.
