Expression of B7-H4 in prostate cancer and its clinical significance.
- Author:
Yun QIAN
1
;
Hang-ping YAO
;
Ling SHEN
;
Lin-fang CHENG
;
Li-huang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; B7-1 Antigen; metabolism; Biomarkers, Tumor; metabolism; Humans; Male; Middle Aged; Prostate; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology; V-Set Domain-Containing T-Cell Activation Inhibitor 1
- From: Journal of Zhejiang University. Medical sciences 2010;39(4):345-349
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.
METHODSImmunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue. And the relationship between the expressions and pathology was evaluated.
RESULTSThe B7-H4 was diffusely expressed in cytoplasm and/or membrane of the prostate cancer tissue; the expression was much higher than that in normal prostate tissue (P<0.05). The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.
CONCLUSIONB7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.
