Promoting effect on NK cells induced by myeloid-derived suppressor cells in acute fulminate hepatitis of mice.
- Author:
Cheng WANG
1
;
Dan-xiao WU
;
Jian-hua LIU
;
Da-jing XIA
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; CD8-Positive T-Lymphocytes; immunology; Female; Hepatitis; etiology; immunology; Killer Cells, Natural; immunology; Lipopolysaccharides; Liver Failure, Acute; chemically induced; immunology; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; immunology; T-Lymphocytes, Regulatory; immunology
- From: Journal of Zhejiang University. Medical sciences 2010;39(4):357-363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the interaction between myeloid-derived suppressor cells (MDSCs) and nature killer cells during acute fulminate hepatitis.
METHODSAcute fulminate hepatitis were induced by i.p. co-injection of LPS and D-GalN in mice, and the ratio of MDSCs,NK cells and the activation of NK cells in different tissues were analyzed by FACS at 0 h,1.5 h,3 h and 6 h.
RESULTSThe percentage of MDSCs and NKG2D+NK cells in different tissues increased as acute fulminate hepatitis progressed, with the increased NK cells in liver tissue. The mean fluorescence intensity of NKG2D on NK cells in different tissues were also enhanced.
CONCLUSIONMDSCs induce the proliferation and activation of NK cells in mice with acute fulminate hepatitis.
