Relationship between hepatitis B virus DNA and hepatitis B virus large envelope protein.
- Author:
Huai-kai WEN
1
;
Jian YU
;
Xiao-yong LI
;
Hong-qun TAO
;
Xin-liang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; DNA, Viral; blood; Female; Hepatitis B virus; physiology; Hepatitis B, Chronic; blood; virology; Humans; Male; Middle Aged; Viral Envelope Proteins; blood; Virus Replication; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2010;39(4):386-389
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between HBV DNA and hepatitis B virus large envelope protein (HBV-LP) in patients with chronic hepatitis B.
METHODSSerum HBV DNA was detected by RT-PCR and the HBV-LP was detected by enzyme linked immunosorbent assay in 320 serum samples collected from patients with chronic hepatitis B.
RESULTSThere were no significant difference between positive rate of HBV-LP and that of HBV DNA in different HBeAg patterns (P>0.05). Serum HBV-LP levels were closely correlated with HBV DNA copies (r=0.949).
CONCLUSIONSerum HBV-LP is a reliable serological marker that can reflect the replication of HBV.
