Expression of vascular endothelial growth factor and microvessel density in hippocampus of rats with aging.
- Author:
Hai-qin WU
1
;
Bei REN
;
Juan-juan SHA
;
Hu-qing WANG
;
Gui-lian ZHANG
;
Ming LI
Author Information
- Publication Type:Journal Article
- MeSH: Aging; Animals; Capillaries; pathology; Hippocampus; blood supply; metabolism; Male; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; genetics; metabolism
- From: Journal of Zhejiang University. Medical sciences 2010;39(4):404-408
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in hippocampus of rats with aging.
METHODSParaffin sections of brain tissue of rats at the age of 3, 18, 24, 30 months were stained by immunohistochemistry, the expression of VEGF and MVD was quantitatively analyzed.
RESULTSInnunohistochemical staining showed that the VEGF-positive cells were mainly pyramidal neuron in hippocampus; the intensity of VEGF-positivity in neuron cells was decreased with the aging (P<0.05). The MVD in hippocampus was also decreased with the aging of rats (P<0.05).
CONCLUSIONIncreasing VEGF contents and improving blood circulation in brain tissue may prevent or treat vascular dementia and cerebrovascular diseases.
