Dual role of transcription factor AP-2 in carcinogenesis.
- Author:
Shuo LIANG
1
;
Hong DENG
Author Information
1. Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Transformation, Neoplastic;
genetics;
Gene Expression Regulation, Neoplastic;
Humans;
Neoplasms;
etiology;
genetics;
Transcription Factor AP-2;
genetics
- From:
Journal of Zhejiang University. Medical sciences
2010;39(4):430-435
- CountryChina
- Language:Chinese
-
Abstract:
Activating protein-2 (AP-2) is a cell type-specific DNA binding transcription factor family with the ability to regulate the expression of specific target genes. Five isoforms of AP-2 have been discovered, they are AP-2alpha, AP-2beta, AP-2gamma, AP-2delta and AP-2epsilon. AP-2s are involved in the regulation of cell proliferation, differentiation and apoptosis as well as embryogenesis of mammary animals. Recently, the function of AP-2 in neoplasm has attracted increasing attention. Researches reveal that the modulation of AP-2 in tumorigenesis may be dual, either inhibitory or promoting, which depends on the specific tissues,stages of cancer progression and difference between five family members. This review summarizes recent research progress on the role of AP-2 in the oncogenesis and their potential applications in clinical practice.
