Research advances of inflammasome and its role in sepsis.
- Author:
Hui LI
1
;
Xiang-Ming FANG
Author Information
1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Caspase 1;
immunology;
metabolism;
Humans;
Inflammasomes;
chemistry;
immunology;
metabolism;
Interleukin-18;
immunology;
metabolism;
Interleukin-1beta;
immunology;
metabolism;
Sepsis;
immunology;
metabolism;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2010;39(5):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasomes are high-molecular-weight, multiprotein complexes in cells, which are assembled after cytoplasmic nucleotide-binding oligomerization domain like receptors (NLRs) sense pathogens and danger signals. The inflammasome can activate caspase-1, and later makes the pro-IL-1β, proIL-18 precursor mature by cleavaging, thereby mediates the innate immunity. Dysregulation of inflammasomes plays an important role in the development of sepsis and other immune inflammatory diseases, thus inflammasome may be a new target for prevention and treatment of sepsis.
