Research advances on hydrogen therapy in nervous system diseases.
- Author:
Yuan HONG
1
;
Sheng CHEN
;
Jian-min ZHANG
Author Information
1. Department of Neurosurgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Antioxidants;
pharmacology;
Humans;
Hydrogen;
pharmacology;
Hydroxyl Radical;
metabolism;
Nervous System;
drug effects;
metabolism;
Nervous System Diseases;
drug therapy;
metabolism;
Oxidative Stress;
drug effects;
physiology;
Peroxynitrous Acid;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2010;39(6):638-643
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
