Research advances on associated genes and pathogenesis of hydrocephalus.
- Author:
Jia-jun ZHOU
1
;
Mei-ping DING
;
Jian-ren LIU
Author Information
1. Department of Neurology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cerebral Ventricles;
pathology;
Disease Models, Animal;
Hydrocephalus;
genetics;
pathology;
Mice;
Mice, Knockout
- From:
Journal of Zhejiang University. Medical sciences
2010;39(6):644-649
- CountryChina
- Language:Chinese
-
Abstract:
Hydrocephalus is a common medical condition characterized by abnormalities in the secretion,circulation or resorption of cerebrospinal fluid (CSF), resulting in ventricular dilatation. The pathogenetic mechanism for the hydrocephalus is attributed to: the overproduction of CSF by the choroid plexus; the defect in CSF absorption and obstruction of CSF flow in the cerebral ventricles. However, the underlying etiology is poorly understood. With the development of genetic engineering, a growing body of evidence indicates that genetic factors play an essential role in the pathogenesis of hydrocephalus. It is the aim of this review to summarize these findings.
