TRPP subfamily and kidney diseases.
- Author:
Jie ZHAO
1
;
Wei YANG
;
Jian-hong LUO
Author Information
1. Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Polycystic Kidney Diseases;
genetics;
metabolism;
TRPP Cation Channels;
chemistry;
genetics;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2010;39(6):650-656
- CountryChina
- Language:Chinese
-
Abstract:
TRPP subfamily is an important member of transient receptor potential family. It has six transmembrane (TM) domains, a large extracellular loop between the first and second TM and 2-4 ankyrin repeats in the N terminal. TRPP subfamily includes TRPP2, TRPP3, TRPP5 etc. There are several differences in their structure, activation mode and function. TRPP subfamily is involved in many physiological mechanisms and its abnormal structure can lead to the formation of polycystic kidney. This subfamily is also closely related to gustation. In this review, we summarize recent research findings of TRPP subfamily and its association with polycystic kidney diseases.
