Involvement of LMO4 in tumorigenesis associated epithelial-mesenchymal transition.
- Author:
Jing-yi LI
1
;
Xiu-jin SHEN
;
Hong DENG
Author Information
1. Department of Pathology and Physiopathology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
Epithelial-Mesenchymal Transition;
Homeodomain Proteins;
metabolism;
physiology;
Humans;
LIM Domain Proteins;
Neoplasms;
metabolism;
pathology;
Signal Transduction;
Transcription Factors;
metabolism;
physiology;
Transforming Growth Factor beta;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2011;40(1):107-111
- CountryChina
- Language:Chinese
-
Abstract:
LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors, so named because they are composed almost entirely of two tandem LIM domains. This subgroup of LIM proteins has 4 members: LMO-1, LMO-2, LMO-3 and LMO-4. They all play important roles in the normal mammalian development, functioning as an important regulator of cell proliferation. LMO4 is highly expressed in the epithelial compartments at locations of active epithelial-mesenchymal interactions, and can interact with some signaling pathways involved in epithelial-mesenchymal signaling. Thus the disregulation of LMO4 expression may be involved in tumorigenesis. In this paper, we will at first expound LMO4 in detail, based on which the possible mechanisms for its interaction with TGF-β signaling and the roles of this cross-talk between them in the vital process of cell will be introduced. All of those will add to our understanding of tumorigenesis and contribute to the search of new targets for the treatment of cancer.
