Protective effect of intranasal cilostazol administration on chronic injury after cerebral ischemia in mice.
- Author:
Qi ZHANG
1
;
Yi-Lu YE
;
Qing LI
;
Wei-Ping ZHANG
;
Li-Li JIANG
;
Er-Qing WEI
;
Yue-Ping YU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Intranasal; Animals; Brain; drug effects; pathology; Brain Ischemia; drug therapy; pathology; Disease Models, Animal; Infarction, Middle Cerebral Artery; drug therapy; pathology; Male; Mice; Neurons; drug effects; pathology; Tetrazoles; administration & dosage; therapeutic use
- From: Journal of Zhejiang University. Medical sciences 2011;40(2):169-175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effect of cilostazol administrated intranasally on chronic injury after focal cerebral ischemia in mice.
METHODSFocal cerebral ischemia in mice was induced by middle cerebral artery occlusion (MCAO). Cilostazol was administrated intranasally or intraperitoneally 1 h, 4 h and 7 h after the operation; then twice a day from the second day for 2 weeks. The neurological deficit scoring and the inclined board testing were performed within 35 d after ischemia. The survival rate, infarct volume and neuron density were assessed 35 d after ischemia.
RESULTIntranasal cilostazol at 0.3 mg/kg increased the survival rate. Intranasal cilostazol (0.3 mg/kg, 1 mg/kg) and intraperitoneal cilostazol (10 mg/kg) significantly attenuated neurological deficit, reduced infarct volume, and increased the survival neuron density in the border of ischemia region.
CONCLUSIONCilostazol administered intranasally demonstrates protective effects on chronic cerebral ischemia in mice.
