Toll-like receptors and their role in pathogenesis and vaccine study of cutaneous diseases.
- Author:
Wei-Wei ZHANG
1
;
Xiao-Hong MAO
Author Information
1. The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Adaptive Immunity;
Immunity, Innate;
Signal Transduction;
Skin Diseases;
immunology;
metabolism;
Toll-Like Receptors;
immunology;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2011;40(2):222-229
- CountryChina
- Language:Chinese
-
Abstract:
Toll like receptor (TLR) can specifically recgnize pathogen-associated molecular patterns (PAMPs) and is considered as an important link between innate and adaptive immunity. It has been shown that TLR plays an important role in the pathogenesis and pathophysiology of a variety of skin diseases. Moreover, TLR agonists have exhibited promising therapeutic effects on the disease models and are expected to be novel vaccine adjuvants. Investigations of the underlying mechanism will give new insights into these diseases. This review will discuss the relationship between TLR and pathogenesis and management of some cutaneous diseases.
