Clinicopathologic study of parvovirus B19 infection in perinatal period.
- Author:
You-ping YANG
1
;
Yang-li ZHU
;
Jian-min ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Anemia; pathology; virology; Autopsy; Biopsy; Erythema Infectiosum; blood; pathology; virology; Erythroblasts; ultrastructure; Female; Fetal Death; Fetus; Humans; Hydrops Fetalis; pathology; virology; Inclusion Bodies; ultrastructure; Infant, Newborn; Lymphohistiocytosis, Hemophagocytic; pathology; virology; Parvovirus B19, Human; isolation & purification; Placenta; pathology; virology; Pregnancy; Stillbirth
- From: Chinese Journal of Pathology 2009;38(2):91-94
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo characterize the risks and histopathological features of parvovirus B19 infection of infants in perinatal period.
METHODSRoutine pathological examination was performed on 1 neonate, 2 dead fetuses and 2 placentas using either autopsy or biopsy materials.
RESULTSThe diagnostic intranuclear inclusions were found in erythroblasts in the bone marrow, liver, spleen and lungs in one case, in the spleen and liver in one case, in the spleen in one case, and in the placentas in two cases.
CONCLUSIONSSevere hemolytic anemia or fetal hydrop or hemophagocytosis caused by the infection of parvovirus B19 can lead to death of infected neonates and fetus. Pathological confirmation of parvovirus B19 infection relies on the identification of erythroblasts containing the diagnostic intranuclear inclusions.
