Small cell variant of peripheral T-cell lymphoma, not otherwise specified: a clinicopathologic and immunophenotypic analysis.
- Author:
Ya-lin LI
1
;
Wei-ping LIU
;
Yuan TANG
;
Sha ZHAO
;
Zhuo ZUO
;
Yong-hong YANG
;
Qun-pei YANG
;
Tian-you LUO
Author Information
- Publication Type:Journal Article
- MeSH: 12E7 Antigen; Adult; Aged; Antigens, CD; metabolism; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; CD3 Complex; metabolism; Cell Adhesion Molecules; metabolism; Cyclophosphamide; therapeutic use; Doxorubicin; therapeutic use; Follow-Up Studies; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Humans; Immunophenotyping; Leukosialin; metabolism; Lymphatic Metastasis; Lymphoma, T-Cell, Peripheral; drug therapy; genetics; metabolism; pathology; Male; Middle Aged; Neoplasm Staging; Prednisone; therapeutic use; Retrospective Studies; Survival Rate; Vincristine; therapeutic use
- From: Chinese Journal of Pathology 2009;38(5):323-328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic features and differential diagnosis of small cell variant of peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS).
METHODSThe clinicopathologic features of 5 cases of small cell variant of PTCL, NOS were retrospectively reviewed, with immunohistochemical study, T-cell receptor (TCR) gene rearrangement analysis and evaluation for Epstein-Barr virus (EBV) status.
RESULTSAll the 5 patients were males. The mean age was 52.6 years. The median duration before diagnosis was 1 month. Clinically, 3 patients presented in stage IV and 2 in stage III. Four of them had generalized lymphadenopathy and splenomegaly. Hepatomegaly and massive effusion were found in 1 and 2 cases, respectively. Marrow involvement was detected in 3 of the 4 patients with bone marrow biopsy performed and one of them also accompanied by lymphocytosis. Histologically, the involved lymph nodes showed partial or complete effacement of nodal architecture and replacement by a monomorphous population of small lymphoid cells. Scanty large lymphoid cells were also identified in 4 cases. Increase in number of blood vessels was noticed in two of them as well. Immunohistochemically, the lymphoma cells in all cases expressed two or more of the T-cell markers and CD43. The staining for CD20, TdT, CD56 and granzyme B was negative. CD99 expression was noted in 3 of the 4 cases. The Ki-67 index ranged from 5% to 15%. Clonal TCRgamma gene rearrangement was detected in the 4 cases studied and one of them also showed TCRbeta gene rearrangement. In-situ hybridization for EBV-encoded RNA was negative in the 4 cases studied. Follow up information was available in 3 of the 5 cases. All of the 3 patients died of the disease, with an average survival of 21.7 months.
CONCLUSIONSmall cell variant of PTCL, NOS represents a rare disease entity which often presents in advanced tumor stage and carries a poor prognosis.