Significance of high-risk human papillomavirus DNA in atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion.
- Author:
Ping MEI
1
;
Yan-hui LIU
;
Min LI
;
Xin-lan LUO
;
Heng-guo ZHUANG
;
Dong-lan LUO
;
Hua-huan LIN
;
Ren-hai ZENG
;
Xiao-bing WANG
;
Li-juan KUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biopsy; Carcinoma, Squamous Cell; pathology; virology; Cervical Intraepithelial Neoplasia; pathology; virology; Colposcopy; DNA, Viral; analysis; Female; Humans; Middle Aged; Papillomaviridae; isolation & purification; Papillomavirus Infections; Precancerous Conditions; pathology; virology; Uterine Cervical Neoplasms; pathology; virology; Uterine Cervicitis; pathology; virology; Vaginal Smears; Young Adult
- From: Chinese Journal of Pathology 2009;38(5):337-339
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore significance of high-risk human papillomavirus (HR-HPV) testing in atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H).
METHODSPresence of HR-HPV DNA was examined in 45 patients with ASC-H using hybrid capture II (HC-II) test. Colposcopic examination and biopsy were taken all results were evaluated.
RESULTSOverall, 33 of 45 (73.3%) ASC-H cases were biopsy proven cervical intraepithelial lesion (CIN). 36 of 45 ASC-H cases were HPV-DNA positive, including 19 cases of HSIL and over lesion; whereas no HSIL or over was found in 9 HR-HPV negative cases. Sensitivity and negativity predictive value of HR-HPV in ASC-H with HSIL and over lesion were both 100%.
CONCLUSIONSASC-H strongly predicts the presence of HSIL, HR-HPV may serve as a predict select whether a patient with ASC-H should take colposcopic examination immediately, patients with positive HR-HPV should undergo immediate colposcopic examination, while negative HR-HPV is an excellent predictor of the absence of HSIL.
