Investigation of compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment VI--improving hyperglycemia-mediated renal damage.
- Author:
Jian-Yang FU
1
;
Xiao-Lin ZHANG
2
;
Jin-Ying TIAN
2
;
Li-Wei HUANG
2
;
Pei-Cheng ZHANG
3
;
Fei YE
2
Author Information
1. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China. rr0543124@126.com
2. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cordyceps;
chemistry;
Diabetic Nephropathies;
drug therapy;
metabolism;
physiopathology;
Drugs, Chinese Herbal;
administration & dosage;
Herb-Drug Interactions;
Humans;
Hyperglycemia;
drug therapy;
metabolism;
physiopathology;
Kidney;
drug effects;
injuries;
physiopathology;
Male;
Metabolic Syndrome;
drug therapy;
metabolism;
physiopathology;
Rats;
Rats, Sprague-Dawley;
Rhodiola;
chemistry;
Rhus;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(22):3961-3966
- CountryChina
- Language:Chinese
-
Abstract:
This study is to investigate the effects of a Chinese prescription (FF), compatibility of Rhodiola crenulata, Cordyceps militaris and Rheum palmatum, on nephropathy in type 1 diabetic rats induced by streptozocin. According to fasting blood glucose level, diabetic rats were divided into three groups: model group, insulin-treated group and FF-treated group. Parameters for evaluating the glucose & lipid metabolism and the renal function were monitored dynamically. Levels of oxidative stress were detected ten weeks later. The results show that FF could significantly decrease the level of serum glucose and lipid profiles, improve the renal functions by decreasing blood urea nitrogen, urine albumin excretion and urease activity; FF could also affect on oxidative stress. In conclusion, Chinese prescription FF could ameliorate hyperglycemia-mediated renal damage in type 1 diabetic rats. These effects may be related to its regulation on the metabolism of glucose and lipid, the microcirculation disturbance and the oxidative stress.
