Long noncoding RNAs in prostate cancer.
- Author:
Zhang-qun YE
1
;
Tao WANG
;
Wen SONG
Author Information
1. Department of Urology, Tongji Hospital, Huazhong University of Science and Technology, Hubei, China. zhangqun_ye@163.com
- Publication Type:Journal Article
- MeSH:
Biomedical Research;
Humans;
Male;
Prognosis;
Prostatic Neoplasms;
RNA, Long Noncoding;
genetics;
physiology
- From:
National Journal of Andrology
2014;20(11):963-968
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) are a group of RNA molecules which are longer than 200 nucleotides. They do not have functional open reading frames and cannot encode proteins. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of gene expression network at epigenetic, transcriptional and post-transcriptional levels, which may affect the growth, proliferation, differentiation, metabolism, apoptosis and other important physiological processes of cells. The abnormal expression of lncRNAs is closely associated with the development, invasion, metastasis and prognosis of tumors. The development of prostate cancer is a multi-factor and multi-step process, in which abnormal gene expression may play an important role. This review focuses on the recent progress in the studies on the role of lncRNAs in prostate cancer, aiming for some new clues to the clinical prevention, diagnosis and treatment of this malignancy.
