Polymorphisms of DNA methyltransferases and the risk of prostate cancer.
- Author:
Bang-Shun HE
1
;
Yu-Qin PAN
;
Cheng-Bin ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Asian Continental Ancestry Group; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferases; genetics; DNA Methylation; Gene Frequency; Genotype; Humans; Logistic Models; Male; Middle Aged; Neoplasm Grading; Polymorphism, Genetic; Prostatic Neoplasms; enzymology; pathology; Repressor Proteins; genetics; Risk
- From: National Journal of Andrology 2014;20(12):1077-1081
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the polymorphisms of DNA methyltransferase (DNMT) and the risk and pathologic characteristics of prostate cancer (PCa) in Chinese men.
METHODSThis case-control study included 155 PCa patients and 155 healthy male controls. Using Sequenom MassARRAY, we detected the genotypes of the DNMT1 polymorphisms rs16999593 and rs2228611 and the DNMT3B polymorphism rs2424908, followed by analysis of their association with the risk and pathologic characteristics of prostate cancer by logistic regression.
RESULTSSignificant differences were found in the frequency of the rs16999593 genotypes (P = 0.041) and that of the rs2424908 genotypes (P = 0.025) between the case and control groups. The frequencies of the genotypes rs16999593CT (OR = 0.61, 95% CI 0.38-0.99, P = 0.043) and rs16999593CT/CC (OR = 0.59, 95% CI 0.39-0.92, P = 0.017) were obviously higher in the control than in the case group, and so were those of rs2424908CT (OR = 0.73, 95% CI 0.58-0.91, P = 0.007) and rs2424908CT/CC (OR = 0.57, 95% CI 0.36-0.94, P = 0.023). The frequencies of rs16999593CT/CC (OR = 0.47, 95% CI 0.28-0.85, P = 0.008) and rs2424908CT/CC (OR = 0.46, 95% CI 0.28-0.85, P = 0.009) were evidently lower in the cases with Gleason score < 7 than in the controls. However, none of the three polymorphisms ex hibited any significant differences in the frequencies of their genotypes between the patients with Gleason score > 7 and the healthy con trols (P > 0.05).
CONCLUSIONThe rs16999593CT/CC genotype of DNMT1 and the rs2424908CT/CC genotype of DNMT3B are as sociated with decreased risk of prostate cancer and lower Gleason score in C.
