Prostate cancer stem cells: advances in current research.
- Author:
Gang WU
;
Deng-long WU
- Publication Type:Journal Article
- MeSH:
Disease Progression;
Humans;
Male;
Neoplasm Recurrence, Local;
Neoplastic Stem Cells;
pathology;
Prostatic Neoplasms;
etiology;
pathology;
Prostatic Neoplasms, Castration-Resistant;
etiology;
pathology
- From:
National Journal of Andrology
2015;21(2):170-174
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is one of the most common malignancies threatening men's health, and the mechanisms underlying its initiation and progression are poorly understood. Last decade has witnessed encouraging progress in the studies of prostate cancer stem cells (PCSCs), which are considered to play important roles in tumor initiation, recurrence and metastasis, castration resistance, and drug resistance. Therefore, a deeper insight into PCSCs is of great significance for the successful management of prostate cancer. This article presents an overview on the location, origin, and markers of PCSCs as well as their potential correlation with tumor metastasis and castration resistance.
