Expressions of Sonic hedgehog and matrix metalloproteinase 2 in human esophageal squamous cell carcinoma and the clinicopathological implications.
- Author:
Zhilong ZHAO
1
;
Lifang ZHANG
;
Jia ZHANG
;
Jiansheng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Carcinoma, Squamous Cell; metabolism; pathology; Esophageal Neoplasms; metabolism; pathology; Female; Hedgehog Proteins; metabolism; Humans; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2; metabolism; Middle Aged; Neoplasm Staging
- From: Journal of Southern Medical University 2013;33(7):1008-1011
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of Sonic hedgehog (Shh) and matrix metalloproteinases 2 (MMP2) in human esophageal squamous cell carcinoma (ESCC) and their association with the clinicopathological features.
METHODSImmunohistochemistry was employed to examine the expressions of Shh and MMP2 in 48 specimens of ESCC and 44 specimens of adjacent tissues.
RESULTSThe positivity rate of Shh expression in ESCC (75%) was significantly higher than that in the adjacent tissues (20.45%). Shh expression was located mainly in the cell nuclei and cytoplasm, and was closely correlated with TNM stage. Positive MMP2 expression was detected in 68.75% of the ESCC tissues as compared to 22.72% in the adjacent tissues. MMP2 expression was localized mainly in the cytoplasm, and its expression level was closely correlated with TNM stage and lymph node metastasis. A positive correlation was found between Shh and MMP2 expressions in the 48 ESCC tissues (R=0.037, P=0.019).
CONCLUSIONThe expression of Shh protein may be involved in tumor invasion and metastasis of ESCC.
