Abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression.
- Author:
Lin SHI
1
;
Anwen ZHANG
;
Yu LUO
;
Shimei ZHAO
;
Haiyan TIAN
;
Yanchu YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cyclin-Dependent Kinase 2; metabolism; Female; Humans; Ki-67 Antigen; metabolism; Male; Middle Aged; Minichromosome Maintenance Complex Component 7; metabolism; Thyroid Neoplasms; metabolism; pathology; Young Adult
- From: Journal of Southern Medical University 2013;33(7):1031-1035
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression, and assess the value of these factors in evaluating tumor cell proliferation activity and the prognosis of the patients.
METHODSImmunohistochemical SP method was used to detect the expressions of MCM7, CDK2 and Ki-67 proteins in 50 cases of thyroid carcinoma, 30 cases of thyroid adenoma, 30 cases of nodular goiter and 20 cases of normal thyroid gland tissues.
RESULTSThe positive rates of MCM7, CDK2 and Ki-67 expressions in thyroid carcinoma were 100% (50/50), 80.00% (40/50) and 84.00% (42/50), significantly higher than the rates in thyroid adenoma, nodular goiter and normal thyroid tissue (P<0.01). In thyroid carcinoma tissues, positive correlations were observed between the expressions of MCM7 and CDK2 proteins (r=0.637, P<0.01), MCM7 and Ki-67 proteins (r=0.633, P<0.01), and CDK2 and Ki-67 proteins (r=0.862, P<0.01).
CONCLUSIONThe high expressions of MCM7, CDK2 and Ki-67 protein may contribute to the development of thyroid carcinoma, and their combined examination may serve as useful index for early diagnosis and prognostic evaluation of thyroid carcinoma. MCM7 is superior to Ki-67 in the evaluation of the thyroid tumor cell proliferation activity.
