Expression of promyelocytic leukaemia protein in Bowen's disease, skin squamous cell carcinoma and basal cell carcinoma.
- Author:
Qiongyu WANG
1
;
Huiqun MA
;
Shijie WANG
;
Yunyun MA
;
Xingwei ZOU
;
Ruilian LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bowen's Disease; metabolism; pathology; Carcinoma, Basal Cell; metabolism; pathology; Carcinoma, Squamous Cell; metabolism; pathology; Female; Humans; Male; Middle Aged; Nuclear Proteins; metabolism; Promyelocytic Leukemia Protein; Skin Neoplasms; metabolism; pathology; Transcription Factors; metabolism; Tumor Suppressor Proteins; metabolism
- From: Journal of Southern Medical University 2013;33(7):1075-1077
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of promyelocytic leukaemia (PML) protein of PML protein in Bowen's disease (BD), skin squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) and explore the role of PML in the pathogenesis of these diseases.
METHODSPML protein in normal skin tissues and lesions of Bowen's disease, SCC and BCC were detected with immunohistochemistry.
RESULTSNormal skin tissues did not express PML protein. In BCC, PML showed rather low expressions in the skin lesions (8.69% in cell nuclei and 4.35% in cytoplasm). The lesions in BD and SCC (grade I and II) showed obvious overexpression of PML protein in the cell nuclei and cytoplasm, and its expression in the cell nuclei of these lesions was significantly higher than that in grade III-IV SCC.
CONCLUSIONPML protein may play an important role in the early stage of SCC, and its overexpression may contribute to the carcinogenesis and metastasis of SCC.
