F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients.
- Author:
Yun Young JUNG
1
;
Hong Il HA
;
Soon Hee JUNG
;
Min Goo LEE
;
Hyean Woo LEE
;
Joon Ho YOON
;
Jong Whan CHOI
;
Byung Il YEH
Author Information
1. Department of Biochemistry and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
CFTR;
mutation;
lung cancer
- MeSH:
Adult;
Aged;
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics;
Female;
Human;
Korea;
Lung Neoplasms/*genetics;
Male;
Middle Age;
*Sequence Deletion;
Support, Non-U.S. Gov't
- From:Experimental & Molecular Medicine
2001;33(1):29-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between lung cancer and the mutations of CFTR gene, we determined amino acid sequences using reverse transcription-polymerase chain reaction (RT-PCR) and DNA sequencing. In this study, the deletion mutation of 508th amino acid in one of nine lung caner patients was found confirming that CFTR gene mutation exists in a Korean lung cancer patient.
