Expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma and their correlation with vasculogenic mimicry.
- Author:
Lan YU
1
,
2
,
3
;
Shiwu WU
;
Lei ZHOU
;
Wenqing SONG
;
Danna WANG
Author Information
- Publication Type:Journal Article
- MeSH: AC133 Antigen; Aged; Aged, 80 and over; Antigens, CD; metabolism; Carcinoma; blood supply; metabolism; Case-Control Studies; Female; Glycoproteins; metabolism; Humans; Immunohistochemistry; Kangai-1 Protein; metabolism; Male; Middle Aged; Peptides; metabolism; Urinary Bladder Neoplasms; blood supply; metabolism
- From: Journal of Southern Medical University 2013;33(9):1336-1340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma, their association with the clinicopathological factors and their roles in vasculogenic mimicry (VM) in the tumor.
METHODSThe expressions of CD133 and CD82/KAI1 and VM were detected by immunohistochemistry and histochemistry in 90 specimens of bladder urothelial carcinoma and 20 specimens of normal bladder epithelium tissue.
RESULTSThe positivity rates of CD133, CD82/KAI1 and VM in normal bladder epithelium tissue were 0, 90% and 0, showing significant differences from the rates of 65.6%, 31.1% and 31.1% in urothelial carcinoma, respectively (P<0.01). Positive expressions of CD133, CD82/KAI1 and VM were significantly correlated with pTNM stage and tumor relapse (P<0.01) but not with gender, age, or tumor numbers (P>0.05). CD133 expression was positively correlated with VM (P=0.487, P<0.05), and CD82/KAI1 expression was negatively correlated with VM (r=-0.452, P<0.01) and CD133 (r=-0.776, P<0.05).
CONCLUSIONThe expressions of CD133 and CD82/KAI1 proteins are involved in the occurrence of VM in bladder urothelial carcinoma to contribute to the invasion and relapse of bladder carcinoma.
