Relationship between heroin spongiform leucoencephalopathy and respiratory chain complex I deficiency.
- Author:
Liang ZHOU
1
;
Minshi LIN
;
Jia YIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Canavan Disease; etiology; metabolism; pathology; Case-Control Studies; Electron Transport; Female; Heroin Dependence; complications; metabolism; pathology; Humans; Male; Middle Aged; Mitochondrial Diseases; metabolism; Young Adult
- From: Journal of Southern Medical University 2013;33(9):1357-1361
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between heroin spongiform leucoencephalopathy and respiratory chain complex I deficiency.
METHODSThe activity of respiratory chain complex I in peripheral white blood cell mitochondria was compared between 36 cases of heroin spongiform leucoencephalopathy and 36 healthy subjects using enzyme-linked immunosorbent assay (ELISA).
RESULTSThe activity of respiratory chain complex I was 5.6∓2.4 U/ml in patients with heroin spongiform leucoencephalopathy, significantly higher than that in the normal subjects (4.2∓2.1 U/ml, t=2.634, P<0.05).
CONCLUSIONIn patients with heroin spongiform leucoencephalopathy, mitochondrial dysfunction results in energy metabolism disorder to cause extensive demyelination of the cerebral white matter. Respiratory chain complex I deficiency of the mitochondria plays a significant role in the pathogenesis of heroin spongiform leucoencephalopathy.
