Expression of pin1 in endometrial carcinoma and its relation with PR.

Author: Yan TIAN ¹ ; Yi ZHANG ; Jingjing YU ; Yu ZHANG
Author Information

1. Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha Hunan, 410078, China.E-mail: lilithtian@163.com.
Publication Type:Journal Article
MeSH: Adult; Biomarkers, Tumor; metabolism; Endometrial Neoplasms; metabolism; pathology; Female; Humans; Lymphatic Metastasis; Middle Aged; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; metabolism; Receptors, Progesterone; metabolism; Uterine Neoplasms; metabolism; pathology
From: Journal of Southern Medical University 2013;33(9):1403-1406
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma.
METHODSThe expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens.
RESULTSPin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression.
CONCLUSIONOur results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.