Effect of losartan on arterial blood pressure and unit discharging of neurons in LHb and MHb of rat.
- Author:
Yu-Zhen PAN
1
;
Xiao-Mei WANG
;
Shui-Sheng WU
;
Shao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Pressure; drug effects; Habenula; drug effects; physiology; Losartan; pharmacology; Neurons; drug effects; physiology; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2002;18(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSTo investigate the effect of 2 mg/kg and 10 mg/kg losartan intraperitoneally (i.p) on arterial blood pressure (AP) and heart rate (HR) in rat and the involvement in the activity of habenulas neurons. Glass micropipette was used to record any changes of unit discharging of neurons in LHb and MHb before and after losartan was intraperitoneally injected.
RESULTSAP and HR were not significantly changed by 2 mg/kg losartan (i.p). However, AP was apparently decreased by 10 mg/kg losartan (i.p), but HR was unchanged. After 10 mg/kg losartan (i.p), 66.66% (12/18) unit discharging of neurons in LHb were increased in frequency, and 61.90% (13/21) in MHb were decreased.
CONCLUSIONAP of rat was significantly decreased by 10 mg/kg losartan (i.p). Depressor effect of losartan (i.p) was involved in the excision of neurons in LHb and the inhibition in MHb.
