Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured hypothalamic cells.
- Author:
Li-Ying WU
1
;
Wei LIU
;
Ai-Shi DING
;
Fu-Zhuang WANG
;
Ming FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Hypoxia; Cells, Cultured; Hypothalamus; cytology; physiopathology; Neurons; physiology; Oxygen; physiology; Patch-Clamp Techniques; Potassium; physiology; Rats; Rats, Wistar; Sodium; physiology
- From: Chinese Journal of Applied Physiology 2002;18(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.
METHODSAfter hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.
RESULTSThe amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.
CONCLUSIONIt is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.
