Current alteration of K(V) channel in SLE patient's peripheral blood lymphocytes and it's significant.
- Author:
Yan HE
1
;
Xiao-Xia SUN
;
Wen-Jie ZHANG
;
Guo-Gan ZHONG
;
Dong-Xiang ZHANG
;
Zhao-Yun YIN
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Cell Membrane; physiology; Flow Cytometry; Humans; Lupus Erythematosus, Systemic; blood; pathology; physiopathology; Lymphocyte Count; Lymphocytes; physiology; Monocytes; metabolism; physiology; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; physiology
- From: Chinese Journal of Applied Physiology 2002;18(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo observe the property alteration of K(v) channel in SLE patient's peripheral blood lymphocyte and its significant.
METHODSThe patch-clamp technique was used to record the current of K(V) channel in SLE patient's peripheral lymphocyte.
RESULTSThe current amplitude of K(V) channel in the SLE patient's lymphocytes decreased, it was (258.6 +/- 112.5) pA in healthy people, but in SLE patient it was (139.4 +/- 58.5) pA (P < 0.05). There was no other changes in the property of channel, include activation potential, inactivation property, channel closing kinetics and its pharmacological property.
CONCLUSIONThe decline of SLE patient's cell immunity may be related to the decrease of the amplitude of K(V) channel current.
