Neuropathologic investigation of area tempestas sclerosis in epileptic sensitive rats.
- Author:
Xin-Lu DU
1
;
Jie ZHAO
;
Wan-Qin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astrocytes; pathology; Epilepsy; pathology; Glial Fibrillary Acidic Protein; metabolism; Male; Neurons; metabolism; pathology; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2002;18(1):84-87
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSThe relation between AT sclerosis (loss of neurons and proliferation of astrocytes) and long-lasting epileptic susceptibility was investigated by thionine staining, GFAP immunohistochemistry and observing the behavior of rats, after scorpion venom (SV) or normal saline (NS) administrated for three week.
RESULTSCompared with NS+ NS group, both the loss of neurons and proliferation of astrocytes were very marked in KA+ NS group (epileptic susceptible rats) (P < 0.05), but those changes were not visible in KA+ NS group (epileptic nonsusceptible rats).
CONCLUSIONSIt suggested that AT sclerosis may be one of important reasons of the long-lasting epileptic susceptibility.
