Insulin resistance model induced by dexamethasone in rats.
- Author:
Fang-Lin ZHANG
1
;
Xiao-Ying LIU
;
Yi-Chuan LINN
;
Kai-Zhen ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; analysis; Dexamethasone; pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Insulin; blood; Insulin Resistance; physiology; Male; Rats; Rats, Sprague-Dawley; Time Factors
- From: Chinese Journal of Applied Physiology 2002;18(1):98-100
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo build a easy and reliable rat model of insulin resistance.
METHODSChanges concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone.
RESULTSThe changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent.
CONCLUSIONIt was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research.
