Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury.
- Author:
Zheng-Jie XU
1
;
Wan-Tie WANG
;
Dong LI
;
Li-Na LIN
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; metabolism; Animals; Female; Lipid Peroxidation; drug effects; Liver; drug effects; metabolism; Male; Malondialdehyde; blood; Pyrazines; pharmacology; Rabbits; Reperfusion Injury; metabolism; Superoxide Dismutase; metabolism; Xanthine Oxidase; metabolism
- From: Chinese Journal of Applied Physiology 2002;18(2):173-175
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the role of ligustrazin on dynamic changes of lipid peroxidation in hepatic ischemia/reperfusion injury (HIRI) and its mechanism.
METHODSThe HIRI model was used. Twenty rabbits were randomly divided into control group (n = 10) and ligustrazin group (n = 10). The xanthine oxidase (XO) activity, superoxide dismutase (SOD) activity,malondialdehyde (MDA) content and glutamic pyruvic transaminase (GPT) activity in plasma were observed before ischemia and at ischemia 25 min, reperfusion 25 min, reperfusion 60 min and reperfusion 120 min.
RESULTSThe XO activity, SOD activity, MDA content and GPT activity of ligustrazin group, as compared with control group, showed significant differences (P < 0.05 or P < 0.01) at total time points of reperfusion.
CONCLUSIONLigustrazin has notable anti-lipid peroxidation effect on HIRI, which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.
