Effect of sex hormones on secretion of lysozyme in alveolar macrophage.
- Author:
Chang-Qing ZHANG
1
;
Cha-Xiang GUAN
;
Fu-Wen ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Androsterone; pharmacology; Animals; Estradiol; pharmacology; Female; Indomethacin; pharmacology; Macrophages, Alveolar; drug effects; enzymology; secretion; Male; Muramidase; metabolism; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2002;18(2):176-178
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSTo further explore the functions of alveolar macrophage and their modulation mechanisms, the activity of lysozyme in rat alveolar macrophage assessed by electrophoresis was determined. The effects of androsterone and estradiol on lysozyme secretion and their mechanisms were also studied.
RESULTSThe results showed that androsterone and estradiol increased activity of lysozyme significantly (P < 0.01), indomethacin abolished those effects. This suggests that the insufficiency of sex hormones secretion as the retrogression of gonads is involved in the decrease of immunological functions, and the susceptibility to infectious diseases.
CONCLUSIONSex hormones increased activity of lysozyme, and those effects related to prostaglandin.
