Effects of morphine on K+ currents in caudate nucleus of neonatal rat.
- Author:
Shu-Zhuo ZHANG
1
;
Yu-Rong LI
;
Li-Jun LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Caudate Nucleus; cytology; drug effects; physiology; Morphine; pharmacology; Neurons; drug effects; physiology; Patch-Clamp Techniques; Potassium Channels; drug effects; physiology; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2002;18(3):226-229
- CountryChina
- Language:Chinese
-
Abstract:
AIMThe effects of morphine on the potassium ionic currents of caudate nucleus neurons of neonatal rat were studied.
METHODSUsing of whole cell voltage clamp technique on caudate nucleus neurons, applied morphine chronically or acutely on it. In order to research the effects of morphine for voltage-gated of potassium ionic currents.
RESULTSThe amplitude of potassium ionic currents are increased by applied morphine acutely in caudate nucleus from (2.6 +/- 0.4) nA to (3.3 +/- 0.5) Na, naloxone can block the effect of morphine on K+ current and the currents are decreased to (2.4 +/- 0.4) nA. If applied morphine in caudate nucleus chronically, the amplitude of potassium ionic currents are increased from (2.6 +/- 0.4) nA to (3.1 +/- 0. 5) nA. After applied naloxone, the currents are decreased to (2.4 +/- 0.4) nA.
CONCLUSIONThe effects of morphine increased potassium ionic currents by micro-opioid receptor mediated and induced the hyper polarization of neurons, leading to inhibition of neural activity.
