The roles of carbon monoxide on hypoxic pulmonary vasoconstriction.
- Author:
Xue-Qin DING
1
;
Gui-Ming LIU
;
Zhuo-Ren SHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carbon Monoxide; physiology; Hypoxia; In Vitro Techniques; Male; Pulmonary Artery; physiology; Rats; Rats, Wistar; Vasoconstriction; physiology
- From: Chinese Journal of Applied Physiology 2002;18(3):261-263
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSTo study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).
RESULTSHypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.
CONCLUSIONZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.
