Toxicity of acrylamide on male reproduction.
- Author:
Hong-Xiu SONG
1
;
Ran WANG
;
Shao-Xian CAO
;
Tie-Zheng LIU
Author Information
1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China. xiuhongsong@163.com
- Publication Type:Journal Article
- MeSH:
Acrylamide;
toxicity;
Animals;
Genitalia, Male;
drug effects;
physiology;
Male;
Sexual Behavior, Animal;
drug effects;
physiology;
Spermatogenesis;
drug effects
- From:
National Journal of Andrology
2008;14(2):159-162
- CountryChina
- Language:Chinese
-
Abstract:
Acrylamide is a common chemical material, extensively used in industry and scientific experiments. Recently, it has been reported that starchy food cooked at high temperature can produce acrylamide. Acrylamide monomer has several toxic effects and the extensive concern for its toxicity has arisen with the finding of acrylamide formation in some processed foods. Researches have shown that acrylamide monomer can cause reproductive toxicity, including toxic effects on male reproductive behavior, male reproductive endocrine function and spermatogenesis. The mechanisms may include the effects of acrylamide on Leydig cells, the formation of motor protein/ chromosomal/DNA alkylation and damage by oxidative stress.
