Grape seed extract inhibits the growth of prostate cancer PC-3 cells.
- Author:
Ting-Ting HUANG
1
;
Xue-Jun SHANG
;
Gen-Hong YAO
;
Jing-Ping GE
;
Wen-Hui TENG
;
Yi SUN
;
Yu-Feng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line, Tumor; Cell Proliferation; drug effects; Cell Survival; drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Kidney; cytology; Male; Plant Extracts; pharmacology; Prostatic Neoplasms; pathology; Rats; Rats, Sprague-Dawley; Seeds; chemistry; Time Factors; Vitis; chemistry
- From: National Journal of Andrology 2008;14(4):331-333
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the inhibitory effect of grape seed extract (GSE) on the growth of prostate cancer PC-3 cells.
METHODSPC-3 cells were treated with GSE at the concentration of 100, 200 and 300 microg/ml for 24, 48 and 72 hours, respectively. The the inhibitory effect of GSE on the growth of the PC-3 cells and the kidney cells of SD rats was determined by MTT reduction assay, with primarily cultured kidney cells of 1-3 days old SD rats as the normal control.
RESULTSGSE significantly inhibited the growth of PC-3 cells in a concentration- and time-dependent manner, but had only a mild inhibitory effect on the kidney cells.
CONCLUSIONGSE inhibits the growth of prostate cancer PC-3 cells and can be used as a new drug for the treatment of prostate cancer.
