Expression of OCTN2 mRNA in the human epididymis and its significance.
- Author:
Dong-Ming GONG
1
;
Zheng LI
;
Xiao-Bin ZHU
;
Yu-Lin LIU
;
Xiao-Rong CAO
;
Yong LIU
;
Yi-Xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Contraception; methods; Epididymis; metabolism; Gene Expression Profiling; Gene Expression Regulation; Humans; Male; Organic Cation Transport Proteins; genetics; RNA, Messenger; genetics; metabolism; Reverse Transcriptase Polymerase Chain Reaction; Solute Carrier Family 22 Member 5
- From: National Journal of Andrology 2008;14(3):242-244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.
METHODSWe collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.
RESULTSOCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.
CONCLUSIONThe human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.
