Buried penis decreases nitric oxide synthase of the corpus cavernosum.
- Author:
Wei-Min YU
1
;
Fan CHENG
;
Xiao-Bin ZHANG
;
Xiu-Heng LIU
;
Yue XIA
;
Ming-Huan GE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Erectile Dysfunction; enzymology; physiopathology; Male; Nitric Oxide Synthase; metabolism; Penis; abnormalities; enzymology; Random Allocation; Rats; Rats, Sprague-Dawley; Spectrophotometry
- From: National Journal of Andrology 2008;14(5):411-413
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of buried penis on nitric oxide synthase (NOS) activity of the corpus cavernosum in rats.
METHODSThe experimental model of concealed penis was established by intra-pocket-suture of the root of the penis. Two hundred and forty rats were equally randomized into a 2, a 4 and a 6 months group, each further divided into a buried (n = 50), a sham operation (n = 15) and a normal subgroup (n = 15). The development of the corpus cavernosum was surveyed by measuring its weight and the ratio to the body weight, followed by determination of NOS activity in the corpus cavernosum by spectrophotometry.
RESULTSNo significant differences were found in the corpus cavernosum weight, the body weight and their ratio among the buried, sham operation and normal groups in any experimental stage (P > 0.05). Buried penis decreased NOS activity in the 4- and 6-month groups (P < 0.05 and P < 0.01) compared with the normal group, but effected no significant change in the 2-month group.
CONCLUSIONBuried penis decreases the NOS activity of the corpus cavernosum in a positively time-related manner, but with no significant influence on its appearance and weight.
