The experimental study of PDLLA/rhBMP-2 compound screws for internal fixation of mandibular fracture.
- Author:
En LUO
1
;
Liwei ZHOU
;
Shicheng WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; administration & dosage; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; administration & dosage; biosynthesis; genetics; Bone Screws; Dogs; Fracture Fixation, Internal; methods; Fracture Healing; Lactic Acid; administration & dosage; Male; Mandibular Fractures; surgery; Polyesters; Polymers; administration & dosage; Recombinant Proteins; administration & dosage; biosynthesis; genetics; Transforming Growth Factor beta
- From: West China Journal of Stomatology 2003;21(6):422-424
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of poly D,L-lactic acid (PDLLA) screws with PDLLA-rhBMP compound on bone regeneration in the screw holes and fracture ends of dog mandibles.
METHODSA self-control study was carried out in 4 dogs. PDLLA/rhBMP-2 compound screws were implanted to fix the mental fractures and PDLLA screws were used as control. The samples from mandibles were collected at 4, 8, 12, 16 weeks after implantation and observed by radiography and histology.
RESULTSAll dogs showed a greater degree of bone regeneration around PDLLA/rhBMP-2 screws than PDLLA ones and all fractures were fixed and healed well.
CONCLUSIONThe PDLLA-rhBMP screw has a better effect of inducing osteogenesis than PDLLA screw, and is able to exert a good fixation to fracture.
