Immunohistochemical study of sialyl Lewis(a) antigen in oral squamous cell carcinoma: the association of sialyl Lewis(a) expression with local lymph metastasis.
- Author:
Lanyan WU
1
;
Qianming CHEN
;
Wei HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, Tumor-Associated, Carbohydrate; analysis; Biomarkers, Tumor; analysis; Carcinoma, Squamous Cell; chemistry; genetics; pathology; secondary; E-Selectin; analysis; genetics; Female; Gangliosides; analysis; genetics; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; chemistry; genetics; pathology
- From: West China Journal of Stomatology 2003;21(6):435-437
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe purpose of this study was to screen sialyl Lewis(a) (sLe(a)) in the tumors of patients with oral squamous cell carcinoma (OSCC) and to explore the association of sialyl Lewis(a) expression with local lymph node metastasis.
METHODSSpecimen from 38 patients with primary OSCC were obtained and analyzed by immunohistochemical methods.
RESULTSThe expression of sLe(a) protein, but not E-selectin, of OSCCs significantly correlated to the local lymph node metastasis. sLe(a) was expressed in 79% (15/19) of the metastatic cases compared with 21% (4/19) of the non-metastasis ones, indicated the association of sLe(a) expression with the local lymph involvement.
CONCLUSIONHigh expression of sLe(a) in OSCC may be related to the metastasis of cervical lymph nodes and it seems useful in predicting poor prognosis in OSCC.
