Effects of aminoguanidine on the expression of NOS in facial nerve and surrounding tissues of traumatic facial paralysis rats.
- Author:
Li-jun WANG
1
;
Shu-xia ZHOU
;
Xiao-ming GU
;
Ying ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Facial Nerve; enzymology; Facial Nerve Injuries; enzymology; Facial Paralysis; enzymology; Guanidines; pharmacology; Male; Muscles; enzymology; Nerve Regeneration; Nitric Oxide Synthase; antagonists & inhibitors; metabolism; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley
- From: West China Journal of Stomatology 2004;22(1):7-9
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.
METHODSA small dose of aminoguanidine were intraperitoneally injected into rats before and after facial paralysis. The facial nerve and surrounding tissues were cut at different time point. Immunohistochemical ABC method was used to study the changes of NOS expression in facial nerve and surrounding tissues.
RESULTSThe inducible NOS immunoreactivity was obvious inhibited in the facial nerve and surrounding tissues in aminoguanidine group.
CONCLUSIONAminoguanidine chronic treatment can obvious inhibit the inducible NOS expression in the facial nerve and surrounding tissues. Aminoguanidine can improve the regeneration of facial nerve and the recovery of traumatic tissues.
