Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma.
- Author:
Wei-dong LENG
1
;
Da-zhang WANG
;
Ge FENG
;
Jia HE
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; biosynthesis; genetics; Adult; Antigens, Neoplasm; Carcinoma, Squamous Cell; metabolism; DNA Topoisomerases, Type II; biosynthesis; genetics; DNA-Binding Proteins; Female; Glutathione S-Transferase pi; Glutathione Transferase; biosynthesis; genetics; Humans; Isoenzymes; biosynthesis; genetics; Male; Middle Aged; Multidrug Resistance-Associated Proteins; biosynthesis; genetics; Neoplasm Proteins; biosynthesis; genetics; Random Allocation; Tongue Neoplasms; metabolism; Vault Ribonucleoprotein Particles; biosynthesis; genetics
- From: West China Journal of Stomatology 2004;22(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with expression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-pi), DNA topo-isomerase II alpha (Topo II alpha).
METHODSThe expression patterns of Pgp, MRP, LRP, GST-pi and Topo II alpha in 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohistochemically labelled streptavidin bioein method (LsAB).
RESULTSThe expression ratios of Pgp, MRP, LRP, GST-pi and Topo II alpha in pre-chemotherapy cases were 47.5%, 50%, 35%, 45%, 82.5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-pi, Topo II alpha and clinic indexes were established (P > 0.05). Expression ratios of Pgp, MRP in post-chemotherapy cases were higher than that in pre-chemotherapy cases (P < 0.05). Expression of Pgp and MRP showed relevance with drug resistance (P < 0.05). The co-expression was common, the ratios of co-expression of Pgp, MRP, GST-pi and MRP, GST-pi in chemotherapy non-responders were 40% and 50%, respectively, but 0 in responders.
CONCLUSIONThe intrinsic multidrug resistance of tongue SCC is relevant to the effects of Pgp, MRP, GST-pi.
