Clinical study of hyaluronic acid in the treatment of chronic periodontitis.

Author: Yi XU ¹ ; M FRENTZEN ; P M Jerve- STORM
Author Information

1. Dept. of Periodontology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Chronic Disease; Dental Scaling; Female; Humans; Hyaluronic Acid; therapeutic use; Male; Middle Aged; Periodontal Pocket; Periodontitis; drug therapy; Root Planing
From: West China Journal of Stomatology 2004;22(1):32-34
CountryChina
Language:Chinese
Abstract:
OBJECTIVEClinical effects in local application of hyaluronic acid (HA) adjunctive to scaling and root planing (SRP) were evaluated.
METHODSIn this cross over design study 20 patients with chronic periodontitis were included. Plaque index, sulcus-fluid-flow-rate (SFFR), sulcus bleeding index, probing pocket depth and attachment level were monitored. All patients were treated with full mouth SRP, in addition a HA gel was administered subgingivally in the test site every week for 6 weeks.
RESULTSA statistically significant improvement of all clinical test parameters was observed in both groups (P < 0.05). Clinically, no significant difference between test and control group could be found. However, the SFFR decreased significantly faster in the test group.
CONCLUSIONNo post-inflammatory tissue regeneration could be achieved by the adjunctive use of HA gel to SRP in the patients with chronic periodontitis. Due to SFFR a control of local inflammation can be achieved quickly.