Study on endotoxin levels of acute and chronic periapical periodontitis.

Author: Tao HU ¹ ; Hong TAN ; Yu-dong XU
Author Information

1. Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Acute Disease; Bacteria; Chronic Disease; Endotoxins; analysis; Humans; Limulus Test; Periapical Periodontitis; metabolism; microbiology; Root Canal Irrigants
From: West China Journal of Stomatology 2004;22(1):52-53
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms.
METHODS10 cases of acute periapical priodontitis(Group 1), 10 cases of chronic periapical periodontitis (group 2, the diameter of apical radiolucency area was less than 2 mm), 10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level.
RESULTSEndotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P < 0.01).
CONCLUSIONEndotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.