Gene expression changes of cartilage matrix of condylar cartilage with anterior disc displacement.
- Author:
Jian-ying FENG
1
;
Kai ZHANG
;
Zhi-yuan GU
;
Takanori SHIBATA
Author Information
- Publication Type:Journal Article
- MeSH: Aggrecans; Animals; Bone Remodeling; Cartilage, Articular; cytology; Chondrocytes; metabolism; Collagen Type II; biosynthesis; genetics; Extracellular Matrix; metabolism; Extracellular Matrix Proteins; biosynthesis; genetics; Female; In Situ Hybridization; Lectins, C-Type; Male; Mandibular Condyle; cytology; metabolism; Proteoglycans; biosynthesis; genetics; RNA, Messenger; biosynthesis; genetics; Rabbits; Temporomandibular Joint; cytology; metabolism; Temporomandibular Joint Disc; surgery; Temporomandibular Joint Disorders; etiology; genetics; metabolism
- From: West China Journal of Stomatology 2004;22(2):100-119
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.
METHODSThe right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.
RESULTSCollagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.
CONCLUSIONAnterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.
