The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas.
- Author:
Lai-kui LIU
1
;
Yi-ning LI
;
Hong-bing JIANG
;
Zhi-xiu HE
;
Xin-zhu YI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Squamous Cell; enzymology; secondary; Female; Humans; Immunohistochemistry; Lymph Nodes; pathology; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2; biosynthesis; Middle Aged; Mouth Neoplasms; enzymology; pathology; Neoplasm Invasiveness
- From: West China Journal of Stomatology 2004;22(2):106-108
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas(OSCC).
METHODSImmunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expression of MMP-2 in OSCC and neck lymph node metastasis were respectively analyzed by statistics.
RESULTSThe results demonstrated that MMP-2 existed in all 71 cases, which the expression of MMP-2 at the OSCC front was more significant than that of MMP-2 at the OSCC center (P < 0.01), and related to neck lymph node metastasis (P < 0.05).
CONCLUSIONThe expression of MMP-2 at the OSCC front could be considered as an index of judging the present of neck lymph node metastasis of OSCC.
