Detection of P-glycoprotein and glutathine S-transferase in mucoepidermoid carcinoma of salivary gland.
- Author:
Jia HE
1
;
Da-zhang WANG
;
Guang-yong ZHENG
;
Ge FENG
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; analysis; Adolescent; Adult; Aged; Antibodies, Monoclonal; analysis; Carcinoma, Mucoepidermoid; immunology; Child; Drug Resistance, Multiple; genetics; Drug Resistance, Neoplasm; genetics; Female; Genes, MDR; Glutathione S-Transferase pi; Glutathione Transferase; analysis; Humans; Isoenzymes; analysis; Male; Middle Aged; Salivary Gland Neoplasms; immunology; Salivary Glands; immunology
- From: West China Journal of Stomatology 2004;22(2):115-151
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study was to investigate the mechanism(MDR) of multidrug resistance(MDR) of mucoepidermoid carcinoma in salivary gland.
METHODS40 cases of mucoepidermoid carcinoma in salivary gland were examined the MDR gene product P-glycoprotein using a monoclonal antibody JSB-1. And 10 of them were also investigated by detecting the expression of GST-pi. All the cases had not been accepted any therapy before the samples were collected.
RESULTS1. Positive expression of JSB-1 was observed in 27 of the 40 specimens. The positive expression was related not only with clinical stage, but also with differentiation degree. 2. The GST-pi positive expression was found in 9 of 10 cases. There was no significant different between the positive expression of JSB-1 and GST-pi.
CONCLUSIONJSB-1 and GST-pi play an important role in MDR of mucoepidermoid carcinoma.
