The association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality.
- Author:
Yan TANG
1
;
Jin-cai ZHANG
;
Wen-hui ZHANG
;
Ruo-yu PANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antigens, CD; genetics; China; ethnology; Chronic Disease; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Middle Aged; Periodontitis; genetics; Polymerase Chain Reaction; methods; Polymorphism, Genetic; Receptors, IgG; genetics
- From: West China Journal of Stomatology 2004;22(2):158-161
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality.
METHODSDNA samples were collected with buccal swabs from 63 patients with severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fc gamma receptor IIA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.
RESULTSIt was found that the frequency of Fc gamma RIIA-R/R131 genotype was significantly higher in patients with severe CP (19.05%) compared to that of the healthy controls (P < 0.0125).
CONCLUSIONThe Fc gamma RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.
